Publication at First Faculty of Medicine |
2012
Abstract
Activation of cannabinoid receptors on synaptic terminals results in regulation of ion channels, neutrotransmitter release and synaptic plasticity. Neuromodulation of synapses by cannabinoids is proving to have a wide range of functional effects, making them potential targets as medical preparations in a variety of illnesses, including some neurodegenerative and mental disorders.
Brain monoamines are involved in many of the same processes affected by neuropsychiatric disorders and by different psychotropic drugs, including cannabinoids. Basic information is summarized in the paper about mechanisms of action of cannabinoids of monoaminergic systems, with a view to inhibition of monoamine oxidase.