Apolipoprotein E epsilon 4-Positive Multiple Sclerosis Patients Develop More Gray-Matter and Whole-Brain Atrophy: a 15-Year Disease History Model Based on a 4-Year Longitudinal Study

Abstract

Multiple sclerosis is a disease with considerable individual variation, and genetic background plays a key role in disease susceptibility adn severity. The objective of the study was to evaluate the relationship between apolipoprotein E (APOE) genotype and the evolution of different clinical and MRI parameters.

Keywords

• multiple sclerosis
• APOE
• brain atrophy
• gray matter
• MRI
• mixed-effect model