Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis

Abstract

Inhibition of hedgehog signalling exerted potent antifibrotic effects in preclinical models of SSc in both preventive and therapeutic settings. These findings might have direct translational implications because inhibitors of Smo are already available and yielded promising results in initial clinical trials.

Keywords

• systemic sclerosis
• fibrosis
• hedgehog signaling
• smo
• LDE223