Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse

Abstract

Survival of the acetylcholinesterase knock-out mouse could be linked to adaptation of many neuronal systems during development including the cholinergic, adrenergic and dopaminergic. These adaptations balance the overstimulation of cholinergic receptors caused by high acetylcholine concentrations and thus maintain homeostasis inside the cell, allowing the animal to live.

Keywords

• AChE-/- mouse
• Cholinergic system
• Dopaminergic system
• Adaptation changes
• Striatum