Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers
2010
Abstract
We investigated in vitro effects of pharmacologically different antidepressants and mood stabilizers on mitochondrial enzymes to discover, which mitochondrial functions could be involved in pathophysiology of mood disorders. Our results indicate that antidepressants may act generally as inhibitors of complex I and complex IV of the electron transport chain.
These mitochondrial enzymes are suggested as proper candidates in searching of new biological markers of mood disorders, targets of new antidepressants or predictors of response to pharmacotherapy