The risk of sporadic colorectal cancer development is not influenced by fat mass and obesity related gene polymorphism in Slavs

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer related mortality worldwide. Both environmental factors (e.g. nutrition, low physical activity, alcohol intake, obesity or smoking) and genetic factors contribute to the individual risk.

The inheritance of CRC is estimated to be about 35%, with only small single gene effects (usual risk ratios are between 1.1 and 1.2); the majority of the causal variants remain unknown.

Keywords

• Colorectal cancer
• CRC
• tumor
• fat mass
• obesity
• gene
• polymorphism