Publikace na 1. lékařská fakulta |
2012
Abstrakt
The aim of the study was to evaluate the importance of screening for thrombophilic mutations after the first early pregnancy loss. Thrombophilic mutations were examinated in a sample of 100 women with at least one miscarriage.
We detected prevalence of factor V and II mutation of 9% and 3%, respectively. Single MTHFR mutation was found in 59% and double heterozygous MTHFR mutation in 23% of cases.
No mutation was present in only 6% of the study group. Heterozygous mutations of factor V occurred 1.8 times more frequently in our study group compared to the general Czech women population.
Also, the frequency of factor II mutation was 1.5-3 times higher.