Anti-Tribbles Homo log 2 (TRIB2) Autoantibodies in Narcolepsy are Associated with Recent Onset of Cataplexy
2010
Abstract
Anti-TRIB2 autoantibodies are prevalent in narcolepsy, the highest positivity was found in HLA-DQB1-0602 positive cases with cataplexy. Their presence is associated with duration of cataplexy, and therefore, depends on duration of illness.
Anti- TRIB2 autoantibodies are strongly associated with narcolepsy close to cataplexy onset (less to 2.3 years). They was rarely found in cases without cataplexy or with distant onset.
The paper brings further support for autoimmune aetiology of the disease, anti-TRIB2 autoantibodies destroy selectively hypothalamic neurons producing hypocretin/orexin.