Restoring assembly and activity of cystathionine beta-synthase mutants by ligands and chemical chaperones

Abstract

The study shows that misfolding of cystathionine beta-synthase mutants can be alleviated by the enzyme ligands and by chemical chaperons.

Keywords

• escherichia-coli
• birth prevalence
• glycine betaine
• heme protein
• homocystinuria
• mutations
• glycerol
• stabilization
• trafficking
• disorders