Effect of fluoxetine and adenosine receptor NECA agonist on G alpha q/11 protein of C6 glioma cells

Abstract

In C6 glioma cells, we studied acute administration of SSRI antidepressants - fluoxetine, sertraline and citalopram. We used immunochemical estimation (ELISA) of the main types of G-protein alpha subunits from isolated membranes of C6 glioma cells.

We also estimated effect of NECA agonist on fluoxetine induced signalling via 1,4,5 IP3 and its levels.

Keywords

• antidepressants
• expression
• infolvement
• activation
• apoptosis
• brain