Effect of methylprednisolone on the axonal impairment accompanying cellular brain oedema induced by water intoxication in rats

Abstract

The effect of MP on axonal impairment during cellular brain oedema induced by water intoxication differs from that during the extracellular osmotic oedema. In the extracellular oedema, cellular metabolism is not significantly affected and myelin changes can be influenced by the neuroprotective effect of MP.

Keywords

• axonal impairment
• water intoxication
• cellular oedema
• methylprednisolone
• neuroprotection
• brain oedema
• myelin staining