Methylprednisolone reduces axonal impairment in the experimental model of brain oedema

Abstrakt

In our earlier paper we demonstrated that opening of the blood-brain barrier with an osmotic insult induces brain oedema which represents a factor triggering axonal impairment accompanied with myelin disintegration. The aim of the present study was to find whether methylprednisolone can reduce such axonal impairment in our model of brain oedema.

Klíčová slova

• axonal impairment
• osmotic blood-brain barrier opening
• methylprednisolone
• neuroprotection
• brain oedema
• myelin staining