Time-dependent axonal impairment in experimental model of brain oedema

Abstract

Opening the blood-brain barrier with an osmotic insult induces brain oedema which represents a factor triggering axonal impairment accompanied with myelin changes. The development of axonal changes initiated by brain oedema only (without ischemia brain injury) is a novel observation.

Keywords

• axonal changes
• osmotic blood-brain barrier opening
• brain oedema
• myelin staining