The risk of transformation in monoclonal gammopathy of undetermined significance in malignant monoclonal gammopathy
Abstract
Monoclonal gammopathy of undetermined significance (MGUS) is defined as a clinically silent symptomless condition where not met diagnostic criteria for multiple myeloma, Waldenstrom macroglobulinemia, AL-amyloidosis or other malignant lymphoproliferative disease. Long-term monitoring has shown that it is possible to premalignant progression to malignant monoclonal gammopathy in approximately 1% of cases a year, probably all cases of MM arise transformation from MGUS.
Within an easy communication, the author tries to answer the question whether it is currently possible to somehow transform MGUS in MM to prevent or at least slow down. The response in MGUS patients is not for now.
Given the much higher level of risk of transformation in patients with asymptomatic multiple myeloma than in MGUS patients, further analysis CMG (Czech myeloma group) is focused on this group of patients with the aim to identify the highest risk patients and then subject them to early and, if possible, non-toxic treatment.