Bosentan in treating vascular complications of systemic sclerosis

Abstract

Systemic Sclerosis (SSc) is a disease of unknown etiology characterized by vasculopathy, fibrosis and autoimmune processes. Digital ischemia presented as Raynaudś phenomenon (RP) or digital ulcers (DUs) is the hallmark of SSc-related vasculopathy.

DU are frequent and are associated with significant morbidity. This paper briefly summarizes the current approach to the treatment of DUs and in addition case report of young female suffering with secondary RP with DUs, treated with bosentan.

Keywords

• systemic sclerosis
• Raynauds phenomenon
• digital ulcers
• treatment
• bosentan