Management of Comorbid/Elderly Patients with Chronic Lymphocytic Leukemia: The role of Dose-reduced Fludarabine Combination Regimens

Abstract

This review article deals with specific aspects of treatment decision-making in older and/or comorbid patients with chronic lymphocytic leukemia; in particular, the article covers the efficacy and toxicity of dose-reduced fludarabine-based regimens in this patient population.

Keywords

• chronic lymphocytic leukemia
• comprehensive geriatric assessment
• fludarabine
• comorbidities
• creatinine clearance