Novel method for rapid copper chelation assessment confirmed low affinity of D-penicillamine for copper in comparison with trientine and 8-hydroxyquinolines

Abstract

This article describes a novel, rapid and inexpensive methodology for assessent of copper chelation. It demonstrates that clioquinol and chloroxin and much more potent copper chelators than D-penicilamine.Moreover, lower binding affinity of D-penicillamine compared with 8-hydroxyquinolines and trientine was demonstrated.

Keywords

• 8-Hydroxyquinolines
• Bathocuproinedisulfonic acid
• Copper
• Chelators
• Penicillamine
• Triethylenetetramine