A study of a new co-processed dry binder based on spray-dried lactose and microcrystalline cellulose
2013
Abstrakt
The paper studies the compressibility and disintegration time of tablets from the co-processed dry binder Disintequik MCC in combination with two lubricants at two concentrations in dependence on compression force. It also compares identical parameters in the physical mixtures of the spray-dried lactose Flowlac 100 and the microcrystalline cellulose Microcel MC-102 in the ratios of 1:9, 2:8 and 3:7 again in combination with two lubricants of two concentrations at one compression force.
The lubricants employed are magnesium stearate and poloxamer 407 in concentrations of 1% and 2%. Compressibility is evaluated by means of energy balance of compression and tensile strength of tablets.