Transfer of metformin across the rat placenta is mediated by organic cation transporter 3 (OCT3/SLC22A3) and multidrug and toxin extrusion 1 (MATE1/SLC47A1) protein

Abstract

In this study we used the model of dually perfused rat placenta to investigate the role of drug transporters in metformin passage across the placenta. We suggest an important role of OCT3 and MATE1 in the transplacental transfer of metformin.

Keywords

• Metformin
• Organic cation transporter 3
• Multidrug and toxin extrusion 1
• Placenta
• Pregnancy
• Gestational diabetes mellitus
• Pharmacokinetics