Development and validation of rapid UHPLC method for determination of aciclovir, its impurities and preservatives in topical cream

Abstract

Novelty and significance of our work is founded in fast analysis of basic aciclovir, its main degradation product guanine and other related substances diguanine, diacetylaciclovir as well as acid parahydroxybenzoates in one analysis.

Keywords

• performance liquid-chromatography
• metabolite 9-carboxymethoxymethylguanine
• human plasma
• human serum
• HPLC assay
• extraction
• column