Improved preparation of beta-D-ManNAc-(1 -> 4)-D-Glc and beta-D-TalNAc-(1 -> 4)-D-Glc disaccharides and evaluation of their activating properties on the natural killer cells NKR-P1 and CD69 receptors

Abstract

The synthetic access of either beta-D-ManNAc-(1-->4)-D-Glc (5) is beta-d-TalNAc-(1-->4)-D-Glc (6) disaccharides has been effectively improved with respect to previous syntheses (J. Carbohydr.

Chem. 2000, 19, 79-91 and 2004, 23, 179-190), optimizing

Keywords

• beta-D-ManNac-(1 -> 4)-D-Glc
• beta-D-TalNAc-(1 -> 4)-D-Glc
• NK cells
• NKR-P1 receptor
• 2-oximino-beta-D-lyxo-hexopyranosides
• reductions
• capsular polysaccharides
• animal lectins
• sugars
• mannosamine
• derivatives
• binding
• protein
• oligosaccharides
• biosynthesis
• inhibition