Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH: Cytochrome P450 reductase null mouse

Abstract

Ellipticine is an antineoplastic agent, which forms covalent DNA adducts mediated by cytochromes P450 and peroxidases. We evaluated the role of hepatic versus extra-hepatic metabolism of ellipticine, using the Hepatic Cytochrome P450 Reductase Null mouse

Keywords

• anticancer drug
• ellipticine
• cytochrome P450
• peroxidase
• DNA adducts
• P-32-postlabelling
• dna adduct formation
• prostaglandin-h synthase
• environmental-pollutant 3-nitrobenzanthrone
• metabolic-activation
• determines susceptibility