Enviromentální polutant 3-nitrobenzanthron indukuje cytochrom P450 1A1 a NAD(P)H:chinon oxidoreductasu v plicích a ledvinách potkana, a tak zesiluje jeho genotoxicitu

Abstrakt

Enviromentální polutant 3-nitrobenzanthron indukuje cytochrom P450 1A1 a NAD(P)H:chinon oxidoreduktasu v plicích a ledvinách potkana, a tak zesiluje jeho genotoxicitu

Klíčová slova

• 3-nitrobenzanthrone
• 3-aminobenzanthrone
• DNA adducts
• NAD(P)H : quinone oxidoreductase
• cytochrome p450 1A1
• induction
• dna adduct formation
• antioxidant-response-element
• prostaglandin-h synthase
• metabolic-activation
• contaminant 3-nitrobenzanthrone
• genetic polymorphisms
• diesel exhaust
• phenol sulfotransferases
• human acetyltransferases
• quinone oxidoreductase