Role of negatively charged amino acids in beta 4 F-loop in activation and desensitization of alpha 3 beta 4 rat neuronal nicotinic receptors

Abstract

The mutations in the F-loop of the ß4 subunit of the nicotinic receptor increased the proportion of the slower desensitization component and increased the response plateau, resulting in decreased receptor desensitization.

Keywords

• nicotinic receptor
• desensitization