On the origin of diastereoselectivity in [2+2+2] cycloisomerization of chiral triynes: Controlling helicity of helicene-like compounds by thermodynamic factors

Abstract

Diastereoselective Co-1-mediated [2 + 2 + 2] cycloisomerization of CH3O-substituted optically pure aromatic triynes to obtain nonracemic functionalized helicene-like compounds (comprising a penta-, hexa-, and heptacyclic helical scaffold) was studied. Th

Keywords

• approximate coulomb potentials
• auxiliary basis-sets
• asymmetric-synthesis
• enantioselective synthesis
• thermal racemization
• catalyzed synthesis
• aromatic triynes
• molecules
• density
• enantiomers