The 14-3-3 protein affects the conformation of the regulatory domain of human tyrosine hydroxylase

Abstract

The main goal of this work was to investigate whether the 14-3-3 protein binding affects the conformation of the regulatory domain of human TH isoform 1 (THIR).

Keywords

• site-directed mutagenesis
• activates tryptophan 5-monooxygenase
• dependent protein-kinase
• amino-acid hydroxylases
• ligand-binding
• catecholamine binding
• phosphorylation
• serine-40
• 3-monooxygenase
• stability