Muscarinic M1 acetylcholine receptors regulate the non-quantal release of acetylcholine in the rat neuromuscular junction via NO-dependent mechanism

Abstract

We found out that oxotremorine selectively inhibits the non-quantal secretion of ACh from motor nerve terminals acting on post-synaptic M1 receptors coupled to Ca2+ channels in the sarcolemma to induce Ca2+-dependent NO synthesis and release.

Keywords

• calcium release
• muscarinic receptors
• neuromuscular junction
• nitric oxide
• NO synthase
• non-quantal acetylcholine release
• nitric-oxide synthase
• non-quantal release
• early postdenervation depolarization
• skeletal-muscle
• transmitter release