Formation and persistence of DNA adducts of anticancer drug ellipticine in rats

Abstract

These results, the first characterization of persistence of ellipticine-DNA adducts in vivo, are necessary to evaluate genotoxic side effects of ellipticine.

Keywords

• ellipticine
• anticancer drug
• DNA adduct
• persistence
• cytochrome p450
• peroxidase
• polycyclic aromatic-hydrocarbons
• human cytochrome-p450 enzymes
• aristolochic acid
• mutation-induction
• cell-cycle
• mouse
• microsomes
• 13-hydroxyellipticine
• 9-hydroxyellipticine
• deoxyguanosine