Disposition of sanguinarine in the rat

Abstract

Sanguinarine is an alkaloid with known antibiotic and anti-inflammatory activity and its pharmacokinetics have been studied in the rat after a single oral dose (10 mgkg(-1) body weight).

Keywords

• sanguinarine
• dihydrosanguinarine
• pharmacokinetics
• biodistribution
• safety evaluation
• argemone oil
• cytotoxicity
• alkaloids