Formation and persistence of DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in target and non-target organs after intratracheal instillation in rats

Abstract

Rats were treated by intratracheal instillation with a single dose of 0.2 mg/kg body wt of 3-nitrobenzanthrone (3-NBA), and persistence of DNA adduct formed by 3-NBA was analyzed.

Keywords

• environmental contaminant 3-nitrobenzanthrone
• polycyclic aromatic-hydrocarbons
• metabolic-activation
• diesel exhaust
• lung-cancer
• p-32-postlabeling analysis
• human acetyltransferases
• v79 cells
• cd-1 mice
• exposure