Structural analysis of cytochromes P450 shows differences in flexibility of heme 2-and 4-vinyls

Abstract

Structural analysis of the orientations of heme vinyl side chains based on published crystallographic data for cytochromes P450. Torsional angles show different distributions for the vinyls in positions 2 and 4.

Keywords

• cytochromes P450
• heme vinyls
• resonance Raman spectra
• enzyme structural flexibility
• resonance raman-spectroscopy
• microsomal cytochrome-p-450
• protein interactions
• crystal-structure
• vinyl
• binding
• resolution
• porphyrin
• ligand