Triterpenoid pyrazines and benzopyrazines with cytotoxic activity

Abstract

Twelve lupane, 18 alpha-oleanane, and des-E-lupane derivatives (1a-5b) were either extracted from natural sources or synthesized from betulinic acid (1a) and betulin (2). Compounds 1b, 1c, 3b, 3c, 4b, 4c, 5a, and 5b were then used as starting materials f

Keywords

• betulinic acid-derivatives
• bis-steroidal pyrazines
• anti-hiv activity
• human-melanoma
• aids agents
• cell-lines
• a-ring
• cephalostatin-1
• inhibitor
• apoptosis