The anticancer drug ellipticine is a potent inducer of rat cytochromes P450 1A1 and 1A2, thereby modulating its own metabolism

Abstract

Ellipticine was found to induce CYP1A1 and/ or 1A2 enzymes and their enzymatic activities and thus increases its own metabolism

Keywords

• DNA ADDUCT FORMATION
• HYDROCARBON RECEPTOR
• LIVER-MICROSOMES
• SUDAN-I
• EXPRESSION
• ENZYMES
• ACTIVATION
• INDUCTION
• BINDING
• CELLS