Studies with the hepatic NADPH:cytochrome P450 reductase null mouse reveal the role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine

Abstract

The role of hepatic cytochrome P450 in the activation of an ellipticine in vivo was evaluated by treating hepatic cytochrome P450 oxidoreductase null- and wild-type mice with this drug

Keywords

• null mouse
• reductase
• cytochrome P450
• ellipticine