Kinetics of ellipticine oxidation by cytochromes P450 1A1 and 1A2 reconstituted with NADPH:cytochrome P450 reductase

Abstract

The results demonstrate that the system of purified CYP1A1 and 1A2 reconstituted with NADPH:CYP reductase oxidizes ellipticine mainly to 9-hydroxy- and 7-hydroxyellipticine

Keywords

• cytochrome P450
• ellipticine
• reductase
• oxidation