Role of oxidative stress in PKC-delta upregulation and cardioprotection induced by chronic intermittent hypoxia

Abstract

The aim was to determine whether increased oxidative stress during the adaptation to chronic intermittent hypoxia (CIH) plays a role in the induction of improved cardiac ischemic tolerance.

Keywords

• ischemia-reperfusion
• oxygen radicals
• infarct size
• protein kinase C
• K-ATP channels
• generating free-radicals
• high-altitude hypoxia
• subcellular-distribution
• glutathione disulfide
• superoxide-dismutase
• cardiac protection
• potassium channels
• n-acetylcysteine