A simple approach to unsymmetric atropoisomeric bipyridine N,N′--dioxides and their application in enantioselective allylation of aldehydes

Abstract

The [2+2+2] cyclotrimerization of 1-isoquinolinyl-1,7-octadiyne with benzonitrile catalyzed by CpCo(CO)2 opened a new pathway for a synthesis of unsymmetrical axially chiral bipyridine N,N'-dioxides.

Keywords

• organic catalysis
• allylation
• asymmteric synthesis
• microwave irradiation
• Lewis bases