PAMAM dendrimeric conjugates with a Gd-DOTA phosphinate derivative and their adducts with polyaminoacids: The interplay of global motion, internal rotation, and fast water exchange

Abstract

Gadolinium(III) complexes of conjugates of PAMAM dendrimers (G1, G2 and G4) and aminobenzylphosphinic acid derivative of DOTA were prepared and their MRI relevant parameters were investigated. Interactions with positively charged polyamino acids were stu

Keywords

• MRI CONTRAST AGENTS
• MAGNETIC-RESONANCE RELAXATION
• MODEL-FREE APPROACH
• LANTHANIDE(III) COMPLEXES
• HIGH-RELAXIVITY
• GADOLINIUM(III) COMPLEX
• COORDINATION SPHERE
• AQUEOUS-SOLUTIONS
• RATIONAL DESIGN
• GD(III) COMPLEX