Some biological actions of PEG-conjugated RNase A oligomers

Abstract

Previously we have shown that monomeric RNase A has no significant biological activity, whereas its oligomers (dimer to tetramer) prepared by lyophilizing from 50% acetic acid solutions, show remarkable aspermatogenic and antitumor activities.

Keywords

• RNase A oligomers
• polyethylene glycol conjugates
• anti-tumor activity
• aspermatogenese melanoma
• bovine seminal ribonuclease
• double-stranded-rna
• antitumor action
• pancreatic ribonuclease
• human-melanoma
• inhibitor
• mice
• increases
• protein
• enzyme