Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

Abstract

The main metabolite of 3-nitrobenzanthrone (3-NBA), 3-aminobenzanthrone (3-ABA), is activated by cytochromes P450 and peroxidases

Keywords

• 3-aminobenzanthrone
• 3-nitrobenzanthrone
• myeloperoxidase
• cytochrome P450
• DNA adducts
• P-32-postlabelling
• carcinogenic aristolochic acids
• prostaglandin-h synthase
• contaminant 3-nitrobenzanthrone
• reductive activation
• human acetyltransferases
• diesel exhaust
• lung-cancer
• v79 cells
• breast
• sulfotransferases