Molecular biology investigation of somatostatin and estrogen receptors in clinically non-functioning pituitary tumors
2013
Abstract
Our aim was to determine the somatostatin (SSTR1–5) and estrogen receptor 1 (ER1) expression profile in 69 specimens of NFA. The expression of the receptors was determined by quantitative real time PCR.
Results were normalized to the beta-glucuronidase housekeeping gene. With exceptions of SSTR4 and SSTR5, all other subtypes of receptors were expressed in the examined tumor specimens.
The median relative quantification values were: 63.8% for SSTR1, 55.4% for SSTR2, 19.6% for SSTR3, 2.6% for SSTR4, 9.2% for SSTR5, and 75.4% for ER1.