Effect of S-adenosylmethionine on acetaminophen-induced toxic injury of rat hepatocytes in vitro

Abstrakt

The study evaluates a possible protective effect of S-adenosylmethionine (SAMe) against acetaminophen-induced toxic injury of primary rat hepatocytes. Co-incubation of hepatocytes with SAMe improved their functional indicators - urea and albumin production.

SAMe also abolished the decrease in the mitochondrial respiration (Complex II) induced by acetaminophen.