Publication at Faculty of Medicine in Hradec Králové |
2009
Abstract
The study evaluates a possible protective effect of S-adenosylmethionine (SAMe) against acetaminophen-induced toxic injury of primary rat hepatocytes. Co-incubation of hepatocytes with SAMe improved their functional indicators - urea and albumin production.
SAMe also abolished the decrease in the mitochondrial respiration (Complex II) induced by acetaminophen.