Abstract
This review summarizes pieces of knowledge about the influence of nitrogen-containing bisphosphonates on cholesterol metabolism. Their mechanism of action is the inhibition of pharnesylpyrophosphate synthetase, an enzyme in cholesterol biosynthesis pathway.
Owing to this ability, positive influence on lipidogram (lowering of serum cholesterol, LDL-cholesterol and increase of HDL-cholesterol) has been demonstrated the majority of clinical studies. There is not enough data about the influence of N-BPs are primary indicated in therapy of bone disorders, their influence on cholesterol synthesis is similar to statins and begs the question about their similar use in clinical practice.