Antioxidants and Vitamins in Clinical Conditions

Abstrakt

Lipids, proteins, carbohydrates and DNA are all capable of reacting with ROS and can be implicated in etiology of various human disorders (rheumatoid arthritis, reperfusion injury, atherosclerosis, lung diseases etc.). In the organism, the damage by ROS is counteracted with natural antioxidants (glutathione peroxidases, superoxide dismutases, catalase, glutathione, ubiquinol, uric acid, and essential minerals) and nutritional antioxidants from diet (i.e. vitamins E, C, carotenoids). Oxidative stress may result from the exposure to a variety of agents including nutrition, pharmacological treatment and environmental pollution.The measurement of DNA damage and repair is a very useful method for monitoring of negative environmental exposure.