Apoptosis and Senescence - Main Mechanisms of Accelerated Aging of Haematopoietic Cells after Irradiation

Abstract

Hematopoietic stem cell (HSC) is one of the most radiosensitive cells in organism. In mice it is characterized as lin-Sca-1+CD117+ cell.

This review discusses role of HSC subpopulations in recovery of hematopoiesis after irradiation, and molecular mechanisms of reaction of HSC to damage induced by genotoxic stress, mainly to double strand breaks of DNA.