Non-steroidal anti-inflammatory drugs (NSAIDs) could cause different injury to the small bowel. The most important and clinically relevant are occult gastrointestinal bleeding (and/or iron deficiency anaemia), acute overt small intestinal bleeding, ulcers, perforation of the small bowel, NSAIDs-induced protein losing enteropathy, dysfunction of the jejunum and/or ileum, intestinal diaphragms.