The effect of folic acid supplementation on the pharmacokinetics and pharmacodynamics of oral methotrexate during the remission-induction period of treatment for moderate-to-severe plaque psoriasis

Abstrakt

The prospective study examined the influence of folic acid (20 mg/week) on the pharmacokinetics of oral methotrexate and its therapeutic effect in patients with plaque psoriasis (PASI score) and toxicity.