Publication at Third Faculty of Medicine, Faculty of Medicine in Hradec Králové |
2007
Abstract
It has been repeatedly shown that statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are very effective in primary and secondary prevention of ischemic heart diseaase. In the settings of acute coronary syndrome (ACS), different pathological pathways are triggered that are known to be inhibited by statins, including endothelial dysfunction and activation of inflammation and coagulation; the idea to use these drugs also under conditions of ACS seems to be, therefore, fully justified