The effect of pH on peroxidase-mediated oxidation of and DNA adduct formation by ellipticine

Abstract

The effect of pH on the efficiency of three model peroxidases (bovine lactoperoxidase, human myeloperoxidase and horseradish peroxidase) in oxidation of ellipticine and in formation ellipticine - DNA adducts

Keywords

• ellipticine
• anticancer drugs
• peroxidases
• cytochrome P450
• oxidations
• DNA adducts
• P-32-postlabeling
• mechanism of activation
• metabolism
• DNA intercalation